郭唱，女，博士，副教授，硕士生导师
电子邮箱：guoc@buct.edu.cn
办公室地址：工程楼B304
微信号：guochang_87533
教育经历
2011.09-2015.07北京化工大学 应用化学专业 理学学士学位
2015.09-2020.07北京化工大学 化学工程与技术专业 工学博士学位
工作经历
2020.08-2023.10 北京化工大学 师资博士后
2023.10-至今2023.12 北京化工大学 讲师
2024.01-至今 北京化工大学 副教授
主持或参与的科研项目
1. 主持：2026-2029 国家自然科学基金面上项目：响应型比率氟磁共振纳米探针的构建与深层组织生物分子定量成像研究，在研
2. 主持：2024-2026 国家自然科学基金青年科学基金项目：基于单原子催化剂的全氟/多氟化合物荧光检测，在研
3. 主持：2023 中央高校基本科研业务费-基地项目：基于金属多酚网络的pH响应型19F MRI纳米探针的构筑及其生物应用研究，已结题
4. 主持：2021-2022 中央高校基本科研业务费-自由探索项目：基于硫化铜的多功能纳米平台用于肿瘤部位19F MRI引导的光热／化学动力学协同治疗，已结题
5. 参与：2024-2028 国家自然科学基金重点项目：新型氢/氟磁共振成像纳米探针的构筑与活体深度组织成像分析，在研
6. 参与：2023-2025 北京市科技项目：基于新型荧光探针的肿瘤类器官培养实时动态评价新方法联合研发及应用，结题
主要研究领域或方向
1. 氟磁共振成像纳米探针的设计与应用
2. 全氟/多氟化合物的检测
代表性论文：
1. Fanqi Liu, Xindi Li, Suying Xu, Chang Guo*, and Leyu Wang*, In Situ Coordination-Assembly Nano-Drugs/Probes for Enhanced Tumor Retention and Responsive Release. Angew. Chem. Int. Ed.2026, 65, e21465.
2. Xiaoyao Xiong, Sijia Li, Yumin Li, Suying Xu, Chang Guo*, and Leyu Wang*. Reversible redox 19F magnetic resonance imaging nanoprobes for monitoring the redox state in vivo.Chem. Sci., 2025,16, 5595-5601.
3. Fanqi Liu, Xindi Li, Yumin Li, Suying Xu, Chang Guo*, and Leyu Wang*. Visualization of drug release in a chemo-immunotherapy nanoplatform via ratiometric 19F magnetic resonance imaging. Chem. Sci., 2024,15, 17397-17406.
4. Luo, Lianying Wang*, Chang Guo*, and Leyu Wang*, Improving Magnetic Resonance Imaging and Chemodynamic Therapy Properties via Tuning the Fe(II)/Fe(III) Ratio in Hydrophilic Single-Atom Nanobowls. ACS Nano 2024, ACS Nano, 2024, 18, 10063-10073.
5. Fanqi Liu, Chang Guo*, Xindi Li, Yumin Li, Suying Xu*, Tony D. James and Leyu Wang*. A versatile nano-transformer for efficient localization-specific imaging and synergistic therapy of bladder cancer. Nano Today. 2024, 54, 102116.
6.Chang Guo#, Xiaoyao Xiong#, Xinxing Zhao#, Yumin Li, Sijia Li, Suying Xu, Tony D. James, Leyu Wang. Superhydrophilic Fluorinated Polymer Probe for Zero-Background 19F MRI with Adaptable Targeting Ability. ACS Applied Materials & Interfaces, 2024, 16, 65319-65327.
7. Chang Guo#, Yunhe Yan#, Suying Xu*, and Leyu Wang*. In situ fabrication of nanoprobes for 19F magnetic resonance and photoacoustic Imaging-Guided Tumor Therapy. Anal. Chem. 2022, 94, 13, 5317–5324.
8. Jiabin Cui, Pin Ma, Weidan Li, Rui Jiang, Lirong Zheng, Yuan Lin, Chang Guo*, Xiong Yin*, and Leyu Wang, Surface active-site engineering in hierarchical PtNi nanocatalysts for efficient triiodide reduction reaction. Nano Res. 2021, 14, 12, 4714-4718.
9.Chang Guo, Qiangqiang Nie, Suying Xu*, and Leyu Wang*. 19F-grafted Fluorescent Carbonized Polymer Dots for Dual-Mode Imaging. Anal. Chem. 2021, 93, 41, 13880–13885.
10. Chang Guo, Yangyang Zhang, Yawei Li, Suying Xu and Leyu Wang. 19F-MRI nanoprobes for the turn-on detection of phospholipase A2 with a low background. Anal. Chem.2019, 91, 8147-8153.
11. Chang Guo, Suying Xu, Anila Arshad and Leyu Wang. A pH-responsive nanoprobe for turn-on 19F magnetic resonance imaging. Chem. Commun., 2018, 54, 9853-9856.
12. Chang Guo, Minmin Xu, Suying Xu and Leyu Wang. Multifunctional nanoprobes for both fluorescence and 19F magnetic resonance imaging. Nanoscale,2017,9, 7163-7168.
招生专业：
招生要求：
认真负责、勤奋踏实、积极上进、学习能力强
