Du, Hongguang
Professor
College of Chemistry
Email:dhg@mail.buct.edu.cn
Lab: 1007 Science and Technology Building
Research Interests
Organic Chemistry and Medicinal Chemistry
Our research focus on synthetic organic methodology, and drug synthesis.
In the first field, we are actively pursuing innovative solutions to establish addition reactions of substituted dihydropyridine compounds with unsaturated compounds, and substitution reactions of substituted dihydropyridine compounds with aromatic compounds.In addition,we are committed to developing new sulfidation reagents for the synthesis of organic sulfur compounds.
In the second field, we are interested in design and synthesis of purine compounds for use as antiplatelet aggregation agents.
Biography
Education &work experience
B.S. ,Beijing University of Chemical Technology,Beijing (1985.9-1989.6)
M.S. ,Beijing University of Chemical Technology,Beijing (1989.9-1992.3)
Ph.D. ,Beijing University of Chemical Technology,Beijing (1996.9-1999.6)
College of Chemistry , Beijing University of Chemical Technology,Beijing (1992.4-Now)
Publications
1. Li Liu, Zikun Deng, Kun Xu*, Pengxing Jiang, Hongguang Du*, and Jiajing Tan*. Access to Deuterated Unnatural α-Amino Acids and Peptides by Photochemical Acyl Radical Addition. Organic Letters. 2021,23(14),5299-5304.
2. Li Liu, Pengxing Jiang,Yongguo Liu,Hongguang Du*and Jiajing Tan*.Direct Radical Alkylation and Acylation of 2H-indazoles Using Substituted Hantzsch Esters as Radical Reservoirs. Org.Chem.Front.,2020,7, 2278–2283.
3.Pengxing Jiang,Li Liu,Jiajing Tan* and Hongguang Du*. Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles.Organic & Biomolecular Chemistry,2021,19,4487-4491.
4. Liu Li; Tan Chen; Fan Rong; Wang Zihan; Du Hongguang*; Xu Kun*; Tan Jiajing*. I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles.Organic & Biomolecular Chemistry (2019), 17(2), 252-256.
5.Peng Qi ,Fang Sun,Ning Chen* and Hongguang Du*.Direct Bis-alkyl Thiolation for Indoles with Sulfinothioates under Pummerer-Type Conditions. The Journal of Organic Chemistry.2022,87（2），1133-1143.
6. Peng Qi, Fang Sun, Ning Chen, and Hongguang Du*;Cross-Dehydrogenative Coupling of Azoarenes with Dialkyl Disulfifides. The Journal of Organic Chemistry，2020,85(13),8588-8596.
7. Xinjie Li, Peng Qi and Hongguang Du* .Cross Dehydrogenation Coupling Reaction of Purine Derivatives with Thioethers. Organic & Biomolecular Chemistry. 2022，20（5），1058-1066.
8. Hu, Junbin; Wang, Chenxing; Yu, Mingwu; Zhang, Shaojuan; Chen, Ning*; Du, Hongguang*.Palladium-Catalyzed N3-Directed C-H Halogenation of N9-Arylpurines and Azapurines.European Journal of Organic chemistry,2022(8), e202101266.
9. Li, Shunlai; Ren, Yajing; He, Qiwen; Wei, Yongji; Du, Hongguang* .Synthesis of novel purine derivatives: Antiplatelet aggregation activity evaluation and 3D-QSAR analysis.Journal of Heterocyclic Chemistry ,2022, 59(11), 2016-2024 .
10. Luyong Li, Jie Hu, Yuqing Fu, Xiaolin Shi, Hongguang Du, Jiaxi Xu * and Ning Chen * , Direct Regioselective C-H Cyanation of Purines, Molecules 2023, 28, 914.
11. Li S, Zhou C, Yu M, He Q, Du H*. Synthesis, anti-platelet aggregation activity evaluation and structure-activity relationships of a series of novel purine derivatives. J Heterocyclic Chem. 2020,57(7),2889-2903.
12. Yu, Mingwu*; Liu, Xiguang; Jiang, Qingsong; Du, Hongguang*. Expeditious synthesis of 9-allenylpurines via cesium carbonate catalyzed isomerization of 9-alkynylpurines. Phosphorus, Sulfur and Silicon and the Related Elements (2018),
193(7), 451-458.
13. Tian, Miao; Chen, Ning*; Xu, Fangming; Li, Xiuxiu; Li, Shunlai; Du, Hong
guang*.Expedient synthesis of 2-alkylthio-N6-aryladenosines from guanosine. Journal of Sulfur Chemistry (2018), 39(1), 8-22.
14. Du, H. G.; Yu, M. W.; Deng, C. E.; Lu, C. H.; Li, S. L. Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D-QSAR of a Series of Novel 6-Alkylamino(Alkoxyl)-2-Propylthio-8-Azapurine Nucleosides. Journal of Heterocyclic Chemistry (2017), 54(1), 436-449.
15. Tian, Miao; Yu, Mingwu; Shi, Tingting; Hu, Junbin; Li, Shunlai; Xu, Jiaxi; Chen, Ning; Du, Hongguang.Silver-Catalyzed Direct C6-H Arylation of Purines and Purine Nucleosides with Arylboronic Acids.European Journal of Organic Chemistry (2017),
2017(24), 3415-3420.
16. Du, Hongguang; Sun, Xiaoyang; Yu, Mingwu; Tian, Miao; Li, Shunlai; Wang, Zhiqian. Synthesis of 8-alkoxy-6-alkylamino-2-alkylthiopurine nucleosides with a straightforward multiple-functionalization strategy. Tetrahedron Letters (2016),
57(27-28), 2949-2953.
17. Mingwu Yu, Zhiqian Wang, Miao Tian, Chenghu Lu, Shunlai Li, and Hongguang Du*,Purinyl N3 Directed Palladium-Catalyzed C−H Alkoxylation of N9 Arylpurines: A Late-Stage Strategy to Synthesize N9 (ortho-Alkoxyl)arylpurines, The Journal of organic chemistry 2016, 81（8）, 3435−3442.
18. Yu Mingwu,Wang Zhiqian,Hu Junbin,Li Shunlai,Du Hongguang. Copper-Catalyzed Intramolecular Alkoxylation of Purine Nucleosides: One-Step Synthesis of 5 '-O,8-Cyclopurine Nucleosides. Journal of Organic Chemistry. 2015,80(19),9446-9453.