Wei Yun
Professor
College of Chemistry
Email:weiyun@mail.buct.edu.cn
Office: 805 Science and Technology Building
Lab: 805 Science and Technology Building
Research Interests
Analytical Chemistry — Separation of bioactive compounds from Natural product; Fabrication of packing column materials or nanomaterials for separation of bioactive compounds; Fabrication of adsorbent for rare earth element or heavy metal ions; Research on detection method for food and environment safety; Fabrication of ultra-stretchable materials for strain or pressure sensors.
Separation of bioactive compounds from Natural product—In this field, we enrich bioactive compounds from plants by a simple enrichment method of solvent flotation, and then separate the enriched mixture of bioactive compounds by high speed countercurrent chromatography (HSCCC) to obtain bioactive compounds with high purity. In addition, we focused on the research of biological activity of the isolated compounds.
Fabrication of adsorbent for rare earth element or heavy metal ions— provide green and simple production methods, as well as high adsorption capacity for rare earth or heavy metal ions. We have been exploring simple and efficient methods to produce green, non-toxic, and biocompatible adsorption materials to solve the water pollution problem. Improving the adsorption capacity of the adsorbent and enhancing its removal rate is our main driving force. In addition, the use of materials for the detection of low content pollutants in water is also of interest, and the combination of detection and adsorption removal is our desired goal.
Fabrication of ultra-stretchable materials for strain or pressure sensors—Inspired by the multi-sensory capabilities of biological skin, we are dedicated to exploring the emerging applications of conductive flexible materials in e-skin, human-machine interfaces, soft robotic and wearable monitoring devices. For the inherent defects of flexible materials, such as low stretchability, high stiffness, and high hysteresis, which can create mechanical mismatches at the tissue-material interface, we are actively seeking innovative solutions to avoid adversely affecting the sensitivity of bioelectronic devices. In addition, designing flexible strain sensors that are self-healing and resistant to dehydration is a major driver of our research.
Research on detection method for food and environment safety—The highly sensitive detection of food, proteins and environmental pollutants through fluorescent probes is a challenge. Our original intention was to construct efficient and sensitive fluorescence detection methods to detect protein cancer biomarkers and environmental pollutants by the fabrication of various fluorescent nanoprobes. In addition, further improving the detection performance of fluorescence sensors is one of our top priorities. We are trying to increase the sensing unit to achieve the distinction of detection targets (such as proteins) so that even in complex detection environments such as human blood, Differentiation of various types of cancer biomarkers can also be achieved. These means and methods have great prospects in chemistry and medicine.
Biography
Education &work experience
B.S. University of Liaoning (1989.9-1993.7)
Ph.D. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences. (1993.9-1998.7)
BIB visiting professor, BIB, Brunel University, UK. (2009.01-2009.04)
NIH visiting professor, National Institutes of Health, USA. (2012.08-2013.08)
Beijing Institute of New Technology Application (1998.7-2004.12)
Beijing University of Chemical Technology (2005.01till now)
Awards &honours
Beijing Nova Program (1999)
New Century Excellent Talents in University, Ministry of Education (2011)
Projects &Funding
Beijing Science Committee Fund (99' Beijing Nova Program),￥200000, 1999.1-2004.12.
Beijing Outstanding Talent Fund Project,￥40000, 2001.1-2003.12.
Beijing Natural Science Fund (Grant No. 2073028), ￥40000, 2007.1-2008.12.
SINOPEC Company (Grant No. 407022), ￥1000000, 2007.1-2008.12.
Ministry of Agriculture of The People’s Republic of China (Grant No. 200803022), ￥2020000, 2008.1-2010.12.
The National Natural Science Foundation of China, General Program (Grant No. 21075007), ￥350000, 2011.1-2013.12.
Program For New Century Excellent Talents in University (Grant No. NCET-11-0563), ￥250000, 2011.1-2013.12.
Beijing Nova Program Interdisciplinary (Grant No. Z141107001814114), ￥60000, 2014.1-2015.12.
Beijing Nova Program Interdisciplinary (Grant No. 2016017), ￥100000, 2016.1-2017.12.
National Key Research and Development Program of China (Grant No. 2017YFF0207803), ￥850000, 2017.7-2019.12.
SINOPEC Research and Development Program (Grant No. 217015-6), ￥1200000, 2017.1-2019.12.
The National Natural Science Foundation of China, General Program (Grant No. 81671411), ￥310000, 2017.1-2019.12.
Ministry of Science and Technology of P. R. China (Grant No. 2019ZX09301-114), ￥441800, 2019.1-2020.12.
SINOPEC Research and Development Program (Grant No. 420008-1), ￥1000000, 2020.1-2022.12.
National Natural Science Foundation of China, General Program (Grant No. 22074004), ￥630000, 2021.1-2024.12.
Publications
[1] Yun Wei*, Ailin Tian, Yan Li, Xiong Wang and Bo Cao. A General Chiral Selector Immobilized on Silica Magnetic Microspheres for Direct Separation of Racemates. J. Mater. Chem. 2012, 22: 8499-8504.
[2] Yun Wei*, Yan Li, Ailin Tian, Yuntian Fan and Xiong Wang. Ionic Liquid Modified Magnetic Microspheres for Isolation of Heme Protein with High Binding Capacity. J. Mater. Chem. B, 2013, 1 (15), 2066-2071.
[3] Lin Chang, Pengyu Bi, Yanan Liu, Yinglin Mu, Fengquan Nie, Shizhong Luo, Yun Wei*. Simultaneous Analysis of Trace Polymer Additives in Plastic Beverage Packaging by Solvent Sublation Followed by High-Performance Liquid Chromatography. J. Agric. Food Chem., 2013, 61, 7165-7171.
[4] Yali Gao, Yanxiang Gu, Yun Wei*, Determination of polymer additives-antioxidants and UV absorbers by High Performance Liquid chromatography coupled with UV photodiode array detection in food stimulants. J. Agri. Food Chem. 2011, 59: 12982-12989.
[5] Lin Chang, Pengyu Bi, Xiaochen Li, Yun Wei*. Study of solvent sublation for concentration of trace phthalate esters in plastic beverage packaging and analysis by gas chromatography-mass spectrometry. Food Chem., 2015, 177, 127-133.
[6] Yun Wei*, Wenwen Huang, Yanxiang Gu. Online Isolation and Purification of Four Phthalide Compounds from Chuanxiong Rhizoma Using Counter-current Chromatography Coupled with Semi Preparative Liquid Chromatography. Journal of Chromatograph A. 2013, 1284, 53-58.
[7] Ailin Tian, Jing Qi, Yating Liu, Fengkang Wang, Yoichiro Ito, Yun Wei*, Chiral magnetic microspheres purified by centrifugal field flow fractionation and microspheres magnetic chiral chromatography for benzoin racemates separation. J. Chromatogr. A, 2013, 1305, 333-337.
[8] Lin Chang, Yun Wei*, Peng-yu Bi, Qian Shao. Recovery of liquiritin and glycyrrhizic acid from Glycyrrhiza uralensis Fisch by aqueous two-phase flotation and multi-stage preparative high performance liquid chromatography, Separation and Purification Technology 2014, 134, 204-209.
[9] Quan Li, Kaite Peng, Yanzhen Lu, Aoxin Li, Fenfang Che, Yuanyuan Liu, Xingjun Xi, Qiao Chu, Tao Lan and Yun Wei*, Synthesis of fluorescent ionic liquid-functionalized silicon nanoparticles with tunable amphiphilicity and selective determination of Hg2+. J. Mater. Chem. B, 2018, 6, 8214-8220.
[10] Yanzhen Lu, Yang Du, Xiaoyan Qin, Huantong Wu, Yong Cheng, Yun Wei*. Comprehensive evaluation of effective polyphenols in apple leaves and their combinatory antioxidant and neuroprotective activities. Ind. Crop. Prod., 2019, 129, 242-252.
[11] Aoxin Li, Hanwen Wu, Yuanjiao Feng, Siyu Deng, Aijiao Hou, Fenfang Che, Yuanyuan Liu, Qianqian Geng, Hanwen Ni and Yun Wei*, A strategy of rapidly screening out herbicidal chemicals from Eucalyptusessential oils. Pest Management Science, 2020, 76, 917-927.
[12] Quan Li, Zhiwei Guo, Xiaoyan Zhao, Taoyi Zhang, Jing Chen, and Yun Wei*, One-pot synthesis of 2,2'-dipicolylamine derived highly photoluminescent nitrogen-doped carbon quantum dots for Fe3+ detection and fingermark detection. Nanotechnology, 2020, 31, 335501.
[13] Zhiwei Guo, Quan Li, Zhiyue Li, Cong Liu, Xuerui Liu, Yuanyuan Liu, Genlai Dong, Tao Lan, Yun Wei*. Fabrication of efficient alginate composite beads embedded with N-doped carbon dots and their application for enhanced rare earth elements adsorption from aqueous solutions. Journal of Colloid and Interface Science 2020, 562, 224-234.
[14] Cong Liu, Wenjuan Wang, Hao Li, Jiangang Liu, Peng Zhang, Yong Cheng, Xiaoyan Qin, Yang Hu and Yun Wei*. The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson’s disease. Food & Function, 2021, 12, 6091-6101.
[15] Quan Li, Zhile Bai, Xingjun Xi, Zhiwei Guo, Cong Liu, Xuerui Liu, Xiaoyan Zhao, Zhiyue Li, Yong Cheng, and Yun Wei*. Rapid microwave-assisted green synthesis of guanine-derived carbon dots for highly selective detection of Ag+ in aqueous solution, Spectrochim. Acta. A., 2021, 248, 119208.
[16] Quan Li, Taoyi Zhang, Jing Chen, Wenxi Ji and Yun Wei*. In situ synthesis of green emitting polydopamine polymer dots based on Fenton reaction for the turn on fluorescence multi-sensing platform. J. Mater. Chem. B, 2021, 9, 5503-5513.
[17] Zhiyue Li, Zhiwei Guo, Taoyi Zhang, Quan Li, Jing Chen, Wenxi Ji, Cong Liu, Yun Wei*, Fabrication of in situ ZIF-67 grown on alginate hydrogels and its application for enhancing Cu(II) adsorption from aqueous solutions, Colloids and Surfaces B: Biointerfaces，2021, 207, 112036.
[18] Jiajia Zeng, Wenjuan Wang, Junjun Lin, Yuchi Zhang, Hao Li, Jiangang Liu, Chen Yan, Yanxiang Gu, Yun Wei*. Purification of menthone and menthol from Mentha haplocalyx by suspension particle assisted solvent sublation, neuroprotective effect in vitro and molecular docking of menthol on amyloid-beta. J. Chromatogr. A, 2022, 1674, 463125.
[19] Qinglong Cao, Zhen Shu, Taoyi Zhang, Wenxi Ji, Jing Chen, Yun Wei*. Highly Elastic, Sensitive, Stretchable, and Skin-Inspired Conductive Sodium Alginate/Polyacrylamide/Gallium Composite Hydrogel with Toughness as a Flexible Strain Sensor. Biomacromolecules, 2022, 23(6), 2603-2613.
[20] Xiao Zhang, Zhiyue Li, Taoyi Zhang, Jing Chen, Wenxi Ji, Yun Wei*. Fabrication of sodium alginate-melamine@ZIF-67 composite hydrogel and its adsorption application for Pb (II) in wastewater. Environmental Science and Pollution Research, 2023, 30, 18364-18379.
[21] Chen Yan, Jiajia Zeng, Hao Li, Xian Pan, Jiangang Liu, Yun Wei*. Research on the chemical composition of Mentha haplocalyx volatile oils from different geographical origins by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry in combination with principal component analysis and the enrichment of bioactive compounds by particle-assisted solvent sublation. Microchemical Journal 2023, 188, 108477.
[22] Zhen Shu, Qinglong Cao, Usman Muhammad, Taoyi Zhang, Wenxi Ji, Jing Chen, Cong Liu, Yun Wei*. Fabrication of high-strength magnetically responsive hydrogels by synergistic salting-out and freezing-thawing and application of their shape deformation and swimming. Polymer Engineering and Science. 2023, 63, 1567-1578.
[23] Chen Yan, Na Li, Yuchi Zhang, Yun Wei*. Enrichment of cinnamaldehyde from cinnamomum cassia by electroosmotic coupled particle-assisted solvent flotation. Journal of Chromatography A. 2023, 1710, 464411.
links：
https://chemistry.buct.edu.cn/2023/0311/c1953a176448/page.htm