Professor
College of Chemistry
Email: fengli2022@buct.edu.cn
Office: 108A Huaxin Building
Lab: 108B Huaxin Building
Phones: 17822009315
Research Interests
Controlled Assembly and Biological Applications of Biomacromolecule — Biomacromolecule self-assembly, Nucleic acid drugs creation, drug delivery systems development.
1) Nucleic acid drugs and their delivery systems, 2) functional DNA assembly systems and their applications in biomedicine, 3) Gene therapy for tumors and rare diseases
Focusing on the controlled assembly and biological application of nucleic acids, we develop a series of nucleic acid molecular material systems by fully integrating the precise control of chemical structure and the biological function of nucleic acid molecules.
Using the developed nucleic acid assembly systems, we constructed nucleoside analogue integrated nucleic acid nanomedicine for cancer gene therapy and antiviral therapy.
Biography
Education &work experience
B.S. Lanzhou University (2006.9-2010.6)
Ph.D. The National Center for Nanoscience and Technology, Chinese Academy of Sciences (2010.9-2015.6)
Post doctor, Tsinghua University (2015.8-2017.12)
Associate professor, Tianjin University (2018.1-2022.4)
Professor, Beijing University of Chemical Technology (2022.4-now)
Projects &Funding
High-level Talents Introduction Program of Beijing University of Chemical Technology
National Natural Science Foundation, General Program:（Grant No. 31971305）
National Natural Science Foundation, Youth Program:（Grant No. 21905196）
Tianjin Municipal Natural Science Foundation, Young Program: Construction of telluride-containing polymer/DNA hybrid hydrogel and the application as three-dimensional cell culture matrix
Beijing Municipal Natural Science Foundation, Young Program:Construction of novel selenium-containing coordination assemblies and their anti-tumor effects and mechanisms
Postdoctoral Foundation, General Program, First Class: Near-infrared photoresponsive platinum nanodrugs based on telluride containing polymers
Publications
1. Yuhang Dong, Yunhua Guo, Wenzhe Song, Guangjun Nie*, and Feng Li*. Functional Integration of DNA and Peptide-Based Supramolecular Nanoassemblies for Cancer Therapy. Accounts of Materials Research, 2023, 4, 10, 892–905.
2. Jing Li+, Jingping Wang+, Ling Chen+, Yuhang Dong+, Haonan Chen+, Guangjun Nie, Feng Li*. Self-Assembly of DNA Molecules at Bio-Interfaces and Their Emerging Applications for Biomedicines. Nano Research, 2023, doi: 10.1007/s12274-023-5597-y.
3. Feng Li, Xiaolei Sun, Jing Yang, Jin Ren, Mengxue Huang, Shengqi Wang*, Dayong Yang*. A Thermal and Enzymatic Dual-Stimuli Responsive DNA-Based Nanomachine for Controlled mRNA Delivery. Advanced Science, 2023, 10, 2204905.
4. Nachuan Song+, Shuai Li+, Zhaoyue Lv+, Xiaohui Ding, Feng Li*, Dayong Yang*. Engineering CRISPR/Cas-based nanosystems for therapeutics, diagnosis and bioimaging. Chinese Chemical Letters, 2023, 108134, doi: 10.1016/j.cclet.2023.108134.
5. Yuhang Dong+, Feng Li+, Zhaoyue Lv, Shuai Li, Meihe Yuan, Nachuan Song, Jinqiao Liu, Dayong Yang*. Lysosome Interference Enabled by Proton-Driven Dynamic Assembly of DNA Nanoframework inside Cells. Angewandte Chemie International Edition, 2022, 61, e202207770.
6. Feng Li+, Yujie Liu+, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang*. Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference. Journal of the American Chemical Society, 2022, 144, 4667-4677.
7. Feng Li+, Nachuan Song+, Yuhang Dong, Shuai Li, Linghui Li, Yujie Liu, Zhemian Li, Dayong Yang*. A Proton-Activatable DNA-Based Nanosystem Enables Co-Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy. Angewandte Chemie International Edition, 2022, 61, e202116569.
8. Huaixin Zhao+, Linghui Li+, Feng Li*, Chunxia Liu, Mengxue Huang, Jiao Li, Feng Gao, Xinhua Ruan, Dayong Yang*. An Energy-Storing DNA-Based Nanocomplex for Laser-Free Photodynamic Therapy. Advanced Materials, 2022, 34, 2109920.
9. Feng Li+, Wenting Yu+, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang*. Spatiotemporally Programmable Cascade Hybridization of Hairpin DNA in Polymeric Nanoframework for Precise siRNA Delivery. Nature Communications, 2021, 12, 1138.
10. Feng Li+, Zhaoyue Lv+, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang*. Supramolecular Self-Assembled DNA Nanosystem for Synergistic Chemical and Gene Regulations on Cancer Cells. Angewandte Chemie International Edition, 2021, 133, 25761.
11. Huaixin Zhao+, Zhili Zhang+, Duo Zuo+, Linghui Li, Feng Li*, Dayong Yang*. A Synergistic DNA-polydopamine-MnO2 Nanocomplex for Near-Infrared-Light-Powered DNAzyme-Mediated Gene Therapy. Nano Letters, 2021, 21, 5477.
12. Feng Li+, Shuai Li+, Xiaocui Guo, Yuhang Dong, Chi Yao, Yangping Liu, Yuguang Song, Xiaoli Tan, Lizeng Gao, Dayong Yang*. Chiral Carbon Dots Mimicking Topoisomerase I to Enantioselectively Mediate Topological Rearrangement of Supercoiled DNA Enantioselectively. Angewandte Chemie International Edition, 2020, 59, 11087.
13. Xiaocui Guo+, Feng Li*, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, Dayong Yang*. Construction of Organelle-Like Architecture via Dynamic DNA Assembly in Living Cells. Angewandte Chemie International Edition, 2020, 59, 20651-20658.
14. Xiaocui Guo+, Feng Li+, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*. Gene Circuit Compartment on Nanointerface Facilitatating Cascade Gene Expression. Journal of the American Chemical Society, 2019, 141, 19171.
15. Feng Li+, Jianpu Tang+, Jinhui Geng, Dan Luo, Dayong Yang*. Polymeric DNA Hydrogel: Design, Synthesis and Applications. Progress in Polymer Science, 2019, 98, 101163.
16. Feng Li+, Yiye Li+, Xiao Yang, Xuexiang Han, Yang Jiao, Taotao Wei, Dayong Yang, Huaping Xu*, Guangjur Nie*. Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine Affecting Cellular Energy Metabolism. Angewandte Chemie International Edition, 2018, 57, 2377-2382.
17. Feng Li, Tianyu Li, Chenxing Sun, Jiahao Xia, Yang Jiao, Huaping Xu*. Selenium-Doped Carbon Quantum Dots (Se-CQDs) for Free Radical Scavenging. Angewandte Chemie International Edition, 2017, 56, 9910-9914.