Liang,Ruizheng

Promulgator：曹鼎Date：2023-12-02Hits：15

Liang Ruizheng

Professor

College of Chemistry

Email:liangrz@mail.buct.edu.cn
Office: 218 Audio-Visual Education Building
Lab: 222 Wuji Building
Phones: +86-15210694977


Research Interests

Inorganic Chemistry — Biomaterials; Intercalation Chemistry; Functional materials.

Our group has conducted an in-depth and systematic fundamental and applied basic research on the controllable preparation and performance regulation of layered double hydroxides (LDHs), constructed a series of new LDH-based biomedical materials and achieved the following innovative achievements:

  • 1) A series of LDH-based photosensitizers with high singlet oxygen yield and near-infrared long wavelength (I–III region) excitation have been developed for photodynamic therapy, of which the excitation wavelength is adjustable in the range of 808-1567 nm, and the singlet oxygen yield up to 0.74-1.06, achieving efficient photodynamic cancer therapy. At the same time, a series of studies based on LDHs have also been carried out in the fields of chemodynamic therapy and sonodynamic therapy.

  • 2) A series of high-performance Mg-based LDHs bioactive bone repair materials have been constructed for osteogenesis, which effectively address the negative effects of rapid degradation of metal magnesium or magnesium alloys, showing the advantages of high efficiency in bone repair. Moreover, application-oriented research and preclinical research of LDH-based anti-osteoarthritis injection have been carried out for efficient treatment of osteoarthritis.

Biography

Education &work experience

  • B.S. Guangxi University, China (2005.9-2009.7)

  • Ph.D. Beijing University of Chemical Technology, China (2009.9-2015.7)

  • Associate professor, Beijing University of Chemical Technology, China (2015.7-2020.12)

  • Professor, Beijing University of Chemical Technology, China (2021.1-Now)

Awards & hornours

  • Second prize of Beijing Science and Technology Progress Award (2022)

  •  “100 Talents Program” of Beijing University of Chemical Technology (2016)

  •  “President’s Scholarship” by Beijing University of Chemical Technology (2014)

  •  “National Scholarship” by Beijing University of Chemical Technology (2013)

Projects &Funding

  • National Natural Science Foundation of China (Excellent Young Scientists Fund) (Grant No. 52322317), ￥2000000, 2024.1-2026.12

  • National Natural Science Foundation of China, General Program (Grant No. 21971007), ￥680000, 2020.1-2023.12

  • Beijing Natural Science Foundation, General Program (Grant No. 2212044), ￥200000, 2021.12-2023.12

Publications

  1. T. Hu, Z. Gu, G. R. Williams, M. Strimaite, J. Zha, Z. Zhou, X. Zhang,* C. Tan,* R. Liang,* Layered double hydroxide-based nanomaterials for biomedical applications, Chem. Soc. Rev., 2022, 51, 6126−6176.

  2. R. Gao,# X. Mei,# D. Yan,* R. Liang,* M. Wei, Nano-photosensitizer based on layered double hydroxide and isophthalic acid for singlet oxygenation and photodynamic therapy, Nat. Commun., 2018, 9, 2798.

  3. W. Shen,# T. Hu,# X. Liu, J. Zha, F. Meng, Z. Wu, Z. Cui, Y. Yang, H. Li, Q. Zhang, L. Gu, R. Liang,* C. Tan,* Defect Engineering of Layered Double Hydroxide Nanosheets as Inorganic Photosensitizers for NIR-III Photodynamic Cancer Therapy, Nat. Commun., 2022, 13, 3384.

  4. T. Hu,# W. Shen,# F. Meng,# S. Yang, S. Yu, H. Li, Q. Zhang, L. Gu,* C. Tan,* R. Liang,* Boosting the sonodynamic cancer therapy performance of 2D layered double hydroxide nanosheet-based sonosensitizers via crystalline-to-amorphous phase transformation, Adv. Mater., 2023, 35, 2209692.

  5. Y. Yang,# T. Hu,# Y. Bian,# F. Meng, S. Yu, H. Li, Q. Zhang, L. Gu, X. Weng,* C. Tan,* R. Liang,* Coupling probiotics with 2D CoCuMo-LDH nanosheets as tumor microenvironment-responsive platform for precise NIR-II photodynamic therapy, Adv. Mater., 2023, 35, 2211205.

  6. W. Liu, S. Xu, S. Guan, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Confined synthesis of carbon nitride in a layered host matrix with unprecedented solid-state quantum yield and stability, Adv. Mater., 2018, 30, 1704376.

  7. Z. Lv,# T. Hu,# Y. Bian,# G. Wang, Z. Wu, H. Li, X. Liu, S. Yang, C. Tan,* R. Liang,* X. Weng*, A MgFe-LDH Nanosheet-Incorporated Smart Thermo-Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration, Adv. Mater., 2023, 35, 2206545.

  8. L. Peng, X. Mei, J. He, J. Xu, W. Zhang,* R. Liang,* M. Wei,* D. G. Evans, X. Duan, Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics, Adv. Mater., 2018, 30, 1707389.

  9. T. Hu, X. Mei, Y. Wang, X. Weng,* R. Liang,* M. Wei,* Two-Dimensional Nanomaterials: Fascinating Materials in Biomedical Field,Sci. Bull., 2019, 64, 1707−1727.

  10. R. Liang, S. Xu, D. Yan, W. Shi, R. Tian, H. Yan, M. Wei,* D. G. Evans, X. Duan, CdTe Quantum Dots/Layered Double Hydroxide Ultrathin Films with Multicolor Light Emission via Layer-by-Layer Assembly, Adv. Funct. Mater., 2012, 22, 4940−4948.

  11. R. Liang, R. Tian, L. Ma, L. Zhang, Y. Hu, J. Wang, M. Wei,* D. Yan,* D. G. Evans, X. Duan, A Supermolecular Photosensitizer with Excellent Anticancer Performance in Photodynamic Therapy, Adv. Funct. Mater., 2014, 24, 3144−3151.

  12. Y. Wang,# S. Shen,# T. Hu, G. R. Williams, Y. Bian, B. Feng, R. Liang,* X. Weng,* Layered Double Hydroxide Modified Bone Cement Promoting Osseointegration via Multiple Osteogenic Signal Pathways, ACS Nano, 2021, 15, 9732−9745.

  13. G. Wang,# Z. Lv,# T. Wang,# T. Hu, Y. Bian, Y. Yang, R. Liang,* C. Tan,* X. Weng,* Surface Functionalization of Hydroxyapatite Scaffolds with MgAlEu-LDH Nanosheets for High-Performance Bone Regeneration, Adv. Sci., 2023, 10, 2204234.

  14. Y. Bian, X. Cai, Z. Lv, Y. Xu, H. Wang, C. Tan,* R. Liang,* X. Weng,* Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment, Adv. Sci., 2023, 10, 2301806.

  15. Y. Zhu#, Y. Wang#, G. R. Williams, L. Fu, J. Wu, H. Wang, R. Liang,* X. Weng,* M. Wei,* Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging-Guided Photothermal and Chemodynamic Therapy, Adv. Sci., 2020, 7, 2000272. (Front Cover)

  16. S. Wang, T. Hu, G. Wang, Z. Wang, D. Yan*, R. Liang,* C. Tan,* Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy, Chem. Eng. J., 2021, 419, 129458.

  17. S. Wang,# S. Yang,# Z. Cui, X. Liu, Y. Yang, T. Wang, W. Ma, Y. Zhou, R. Liang,* D. Yan,* H. Chen,* In-situ Activation of CuAl-LDH Nanosheets to Catalyze Bioorthogonal Chemistry in vivo in Tumor Microenvironment for Precise Chemotherapy and Chemodynamic Therapy, Chem. Eng. J., 2023, 457, 141186.

  18. Z. Cui,#T. Hu,# S. Yang, Y. Yang,X. Liu,T. Wang, H. Chen, C. Zeng*, R. Liang*, Y. Zhou*, Amorphous 2D Mn-doped CoMo-layered double hydroxide nanosheets for magnetic resonance imaging-guided sonodynamic cancer therapy. Chem. Eng. J., 2023, 17, 147463.

  19. X. Mei, W. Wang, L. Yan, T. Hu, R. Liang,* D. Yan,* M. Wei,* David G. Evans, Xue Duan, Hydrotalcite Monolayer toward High Performance Synergistic Dual-modal Imaging and Cancer Therapy, Biomaterials, 2018, 165, 14−24.

  20. X. Mei#, T. Hu#, H. Wang, R. Liang,* W. Bu,* M. Wei,* Highly dispersed Nano-enzyme Triggered Intracellular Catalytic Reaction toward Cancer Specific Therapy,Biomaterials, 2020, 258, 120257.

  21. J. Wu, G. R. Williams, Y. Zhu, T. Hu, H. Wang, W. Zhao, R. Liang,* X. Weng,* M. Wei,* Ultrathin Chalcogenide Nanosheets for Photoacoustic Imaging-Guided Synergistic Photothermal/Gas Therapy, Biomaterials, 2021,273, 120807.

  22. T. Hu,# Q. Liu,# Z. Zhou,# W. Zhao, H. Huang, F. Meng, W. Liu, Q. Zhang, L. Gu, R. Liang,* C. Tan,* Preparation of Dye Molecule-Intercalated MoO3 Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging-Guided Catalytic Therapy,Small, 2022, 18, 2200595.

  23. T. Hu, Z. Wang, W. Shen, R. Liang,* D. Yan,* M. Wei,* Recent advances in innovative strategies for enhanced cancer photodynamic therapy, Theranostics, 2021, 11, 3278−3300.

  24. T. Hu, B. Xue, F. Meng, L. Ma, Y. Du, S. Yu, R. Ye, H. Li, Q. Zhang, L. Gu, Z. Zhou,* R. Liang,* C. Tan,* Preparation of 2D polyaniline/MoO3-x superlattice nanosheets via intercalation-induced morphological transformation for efficient chemodynamic therapy, Adv. Healthcare Mater., 2023, 12, 2202911.

  25. J. Zhang,# Y. Yang,# F. Qin,# T. Hu, X. Zhao, S. Zhao, Y. Cao, Z. Gao, Z. Zhou,*R. Liang,* C. Tan,* Y. Qin, Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy, Adv. Healthcare Mater., 2023, 12, 2302056.

  26. R. Liang, D. Yan, R. Tian, X. Yu, W. Shi, C. Li, M. Wei*, D. G. Evans, X. Duan, Quantum Dots-Based Flexible Films and Their Application as the Phosphor in White Light-Emitting Diodes, Chem. Mater., 2014, 26, 2595−2600.

  27. W. Liu, S. Xu, Z. Li, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Layer-by-Layer Assembly of Carbon Dots-Based Ultrathin Films with Excellent Quantum Yield and Temperature Sensing Performance, Chem. Mater., 2016, 28, 5426−5431.

  28. J. Wu#, S. Zhang#, X. Mei, N. Liu, T. Hu, R. Liang,* D. Yan,* M. Wei,* Ultrathin Transition Metal Chalcogenide Nanosheets Synthesized via Topotactic Transformation for Effective Cancer Theranostics, ACS Appl. Mater. Interfaces, 2020, 12, 48310−48320.

  29. X. Mei, S. Xu, T. Hu, L. Peng, R. Gao, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs, Nano Res., 2018, 11, 195–205.

  30. R. Liang, S. You, L. Ma, C. Li, L. Zhang, M. Wei*, D. Yan*, M. Yin*, W. Yang, D. G. Evans, X. Duan, A Supramolecular Nanovehicle toward Systematic and Targeted Cancer Therapy, Chem. Sci., 2015, 6, 5511−5518.

  31. X. Mei, J. Ma, X. Bai, X. Zhang, S. Zhang, R. Liang,* M. Wei,* D. G. Evans, X. Duan, A bottom-up synthesis of rare-earth-hydrotalcite monolayer nanosheets toward multimode imaging and synergetic therapy, Chem. Sci., 2018, 9, 5630−5639.

  32. T. Hu#, L. Yan#, Z. Wang, W. Shen, R. Liang,* D. Yan,* M. Wei,* A pH-responsive Ultrathin Cu-based Nanoplatform for Specific Photothermal and Chemodynamic Synergistic Therapy,Chem. Sci., 2021, 12, 2594–2603.

  33. X. Mei, T. Hu, Y. Wang, X. Weng,* R. Liang,* M. Wei,* Recent advancements in two-dimensional nanomaterials for drug delivery, WIREs Nanomed Nanobiotechnol., 2020, 12, e1596.

  34. J. Wu, T. Hu, G. Zhao,* A. Li,* R. Liang,* Two-dimensional transition metal chalcogenide nanomaterials for cancer diagnosis and treatment, Chin. Chem. Lett.,2022, 33, 4437–4448.

  35. Z. Zhou,# T. Wang,# T. Hu,# C. Cheng, S. Yu, H. Li, S. Liu, L. Ma, M. Zhao,* R. Liang,* C. Tan,* Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy, Mater. Chem. Front., 2023, 7, 1684–1693.

  36. Z. Cao,# Y. Ban,# T. Hu, Y. Yang, Z. Cui, T. Wang, S. Yang, X. Weng,* R. Liang,* C. Tan,* Recent advances in two-dimensional nanomaterials for bone tissue engineering, J. Materiomics, 2023, 9, 9304–958.

  37. R. Tian, D. Yan, C. Li, S. Xu, R. Liang,* L. Guo, M. Wei,* D. G. Evans, X. Duan, Surface-confined fluorescence enhancement of Au nanoclusters anchoring to a two-dimensional ultrathin nanosheet toward bioimaging, Nanoscale, 2016, 8, 9815–9821.

  38. S. Guan, Y. Weng, M. Li, R. Liang,* C. Sun,* X. Qu,* S. Zhou, An NIR-sensitive layered supramolecular nanovehicle for combined dual-modal imaging and synergistic therapy, Nanoscale, 2017, 9, 10367–10374.

  39. Y. Wang, X. Mei, Y. Bian, T. Hu, X. Weng,* R. Liang,* M. Wei,* Magnesium-based layered double hydroxides nanosheets: a new bone repair material with unprecedented osteogenic differentiation performance, Nanoscale, 2020, 12, 19075−19082. (Front Cover)

  40. W. Liu, S. Xu, R. Liang,* M. Wei,* D. G. Evans, X. Duan, In situ synthesis of nitrogen-doped carbon dots in the interlayer region of a layered double hydroxide with tunable quantum yield, J. Mater. Chem. C, 2017, 5, 3536−3541.

  41. S. Guan, R. Liang,* C. Li, D. Yan,* M. Wei,* D. G. Evans, X. Duan, A layered drug nanovehicle toward targeted cancer imaging and therapy, J. Mater. Chem. B, 2016, 4, 1331–1336.

  42. X. Mei, R. Liang,* L. Peng, T. Hu, M. Wei,* Layered double hydroxide bio-composites toward excellent systematic anticancer therapy, J. Mater. Chem. B, 2017, 5, 3212−3216.

  43. L. Yan#, Y. Wang#, T. Hu#, X. Mei, X. Zhao, Y. Bian, L. Jin, R. Liang,* X. Weng,* M. Wei,* Layered Double Hydroxides Nanosheets: toward Ultrasensitive Tumor Microenvironment Responsive Synergetic Therapy, J. Mater. Chem. B, 2020, 8, 1445−1455.

  44. Z. Wang#, L. Fu#, Y. Zhu, S. Wang, G. Shen, L. Jin,* R. Liang,* Chemodynamic/photothermal synergistic therapy based on Ce-doped Cu-Al layered double hydroxide, J. Mater. Chem. B, 2021, 9, 710–718.

  45. A. Wang, W. Yang, X. Yang, X. Mei, T. Hu, R.Liang,* D. Meng,* D. Yan,* MgAl monolayer hydrotalcite increases the hypoglycemic effect of berberine by enhancing its oral bioavailability, Biomed. Pharmacother., 2020, 127, 110140.

  46. S. Guan, R. Liang,* C. Li, M. Wei,* A supramolecular material for dual-modal imaging and targeted cancer therapy, Talanta, 2017, 165, 297–303.

  47. Y. Wang, Y. Bian, L. Zhou, B. Feng,* X. Weng,* R. Liang,* Biological evaluation of bone substitute, Clinica Chimica Acta,2020, 510, 544–555.

  48. T. Hu, J. He, S. Zhang, X. Mei, W. Zhang,* R. Liang,* M. Wei,* D. G. Evans, X. Duan, An ultrathin photosensitizer for simultaneous fluorescence imaging and photodynamic therapy, Chem. Commun., 2018, 54, 5760−5763.

  49. R. Liang, R. Tian, W. Shi, Z. Liu, D. Yan, M. Wei*, David G. Evans, Xue Duan, A temperature sensor based on CdTe quantum dots−layered double hydroxide ultrathin films via layer-by-layer assembly, Chem. Commun., 2013, 49, 969−971.

  50. R. Liang, M. Wei,* D. G. Evans, X. Duan, Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics, Chem. Commun., 2014, 50, 14071−14081.

  51. R. Liang, L. Ma, L. Zhang, C. Li, W. Liu, M. Wei*, D. Yan*, D. G. Evans, X. Duan, A Monomeric Photosensitizer for Targeted Cancer Therapy, Chem. Commun., 2014, 50, 14983−14986.

  52. M. Li, R. Tian, D. Yan, R. Liang,* M. Wei,* D. G. Evans, X. Duan, A luminescent ultrathin film with reversible sensing toward pressure, Chem. Commun., 2016, 52, 4663–4666.

  53. Z. Wang, T. Hu, R. Liang,* M. Wei,* Application of Zero-Dimensional Nanomaterials in Biosensing, Front. Chem., 2020, 8, 00320.

  54. R. Liang, R. Tian, Z. Liu, D. Yan,* M. Wei, Preparation of Monodisperse Ferrite Nanocrystals with Tunable Morphology and Magnetic Properties, Chem. Asian J., 2014, 9, 1161–1167.

  55. L. Fu, H. Liu, L. Yan, Y. Fu, Y. Zhu, L. Jin,* R. Liang,* Fabrication of CuNCs/LDHs Films with Excellent Luminescent Properties and Exploration of Thermosensitivity, Ind. Eng. Chem. Res., 2019, 58, 8009−8015.

  56. C. Li, R. Liang,* R. Tian, S. Guan, D. Yan, Ji. Luo,* M. Wei,* D. G. Evans, X. Duan, A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy, RSC Adv., 2016, 6, 16608–16614.

  57. X. Liu, T. Hu, G. Lin, X. Wang, Y. Zhu, R. Liang,* W. Duan,* M. Wei, The synthesis of a DHAD/ZnAlTi-LDH composite with advanced UV blocking and antibacterial activity for skin protection, RSC Adv., 2020, 10, 9786−9790.

  58. X. Mei, L. Peng, R. Liang,* M. Wei,* The fabrication of layered double hydroxides based bio-materials and their application in theranostic and drug delivery,Scientia Sinica Chimica, 2017, 47, 431−441.

  59. T. Hu,# Z. Zhou,# J. Zha, G. R. Williams, Z. Wu, W. Zhao, W. Shen, H. Li, X. Weng,* R. Liang,* C. Tan*, Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy, Fundam. Res., 2022, DOI: 10.1016/j.fmre.2022.06.001.

  60. Y. Bian#, T. Hu#, Z. Lv, Y. Xu, Y. Wang, H. Wang, W. Zhu, B. Feng, R. Liang,* C. Tan,* X. Weng,* Bone tissue engineering for treating osteonecrosis of the femoral head, Exploration, 2023, 3, 20210105.

  61. Z. Zhou, X. Li, T. Hu, B. Xue, H. Chen, L. Ma, R. Liang,* C. Tan,* Molybdenum-based nanomaterials for photothermal cancer therapy, Adv. NanoBiomed Res., 2022, 2, 2200065.

links：

https://chemistry.buct.edu.cn/2023/0223/c1955a175999/page.htm

https://www.x-mol.com/groups/liang_rz